FOR YOUR HEALTH: Helping The Nervous System Heal Itself

When Codi Darnell was injured in a fall, her father-in-law, Dr. Harold Punnett, co-founded a pharmaceutical company to seek a cure for her spinal cord injury.

(NAPSI)—For decades, medical researchers struggled to solve the mystery of how to reverse paralysis caused by serious spinal cord injuries. Finally, hope appears to be at hand.

Making Mice Move

Remarkable video footage shows how paralyzed mice regained some of their ability to walk again after receiving an experimental drug treatment.

The injectable pre-clinical therapy, which is designed to regenerate nerve cells in spinal cord injuries, is being developed by researchers at Northwestern University in Evanston, Illinois.

However, the scientists have yet to make the big leap from animal to human clinical trials, meaning that this drug candidate is quite a few years from potentially being approved by government regulators for commercialization.

Clinical Trial

Another experimental therapy has achieved even more impressive results with most laboratory rodents regaining coordinated movement—even enabling previously paralyzed rats to climb tiny ladders—and it is much further along on the developmental curve.

This novel drug candidate is known as NVG-291 and is the brainchild of a renowned neuroscientist, Dr. Jerry Silver, who has licensed his technology to a Canadian life sciences company, NervGen Pharma Corp.

Five years ago, Codi Darnell, the daughter-in-law of Dr. Harold Punnett, a co-founder of NervGen, fell and became a complete T-11 paraplegic. Dr. Punnett discovered a revolutionary nerve regeneration technology in Dr. Jerry Silver’s work at Case Western Reserve University which resulted in the formation of NervGen.

Dr. Silver’s innovation offers renewed hope for the estimated 300,000 to 500,000 North Americans who dream of one day regaining sensation and motor function in their paralyzed limbs. This is similarly the case for more than a million Americans who have debilitating peripheral nerve injuries.

With no approved pharmaceuticals for spinal cord injury, it is heartening that NVG-291 is undergoing Phase 1 clinical trials, aimed at demonstrating its safety and lack of toxicity in healthy human trial volunteers.

This drug candidate is primed for important studies in patients in 2022. This is when its efficacy will be put to the test for the first time in humans afflicted by a range of debilitating spinal cord injuries and other nerve damage. Dr. Silver says he expects to get impressive results due to the surprising similarity between the central nervous systems of rats and humans.

His advanced-stage research work has taken on a greater urgency as the pharmaceutical industry has yet to bring to market any drugs that are able to repair injured nerves and let patients regain or improve key bodily functions. Unfortunately, current treatments that simply slow down or mitigate the debilitating effects on the human body resulting from the mass death of neurons in the brain or spine do not work in spinal cord injury.

Accordingly, Dr. Silver envisions that NVG-291 has the potential to revolutionize the treatment of spinal cord injuries. This is because it is designed to heal nerve damage by unleashing the body’s natural ability to repair itself. NVG-291 doesn’t just repair nerve cells, it creates new neural pathways via the extraordinary process of neural plasticity.

This work has been independently replicated in a German laboratory by other scientists, who also used rats. Interestingly, they used doses of NVG-291 that were 50 times higher than used by Dr. Silver. The study achieved even better recovery outcomes, while noting no toxicity issues with the rats from experiencing such comparably high doses.

Dr. Silver says, “It is our hope that this technology can improve the lives of the many people living with debilitating nerve damage. And we’re very confident that we’re on the right track.”

Learn More

For more facts, see www.nervgen.com.

REVIEW POTPOURRI: Ralph Vaughan Williams, Stephen King & Calvin Coolidge

Peter Catesby Peter Cates

Ralph Vaughan Williams

Ralph V. Williams

I first became attracted to the music of English composer Ralph Vaughan Williams (1872-1958) back during high school when I heard a recording of his London Symphony at a friend’s house and shortly after ordered it by mail from King Karol Records in New York City, now long closed.

The London Symphony was composed in 1920, is the second of his Nine Symphonies and is a celebration of the panoramic beauty of London. He used the full orchestra to convey its sights and sounds – the early morning awakening of the city, the streetcars and trolleys rushing its citizens to work, the hush of quiet side streets during the afternoon lull and at twilight, and the movement of ships down the Thames River towards the ocean. The Big Ben Clock chimes its 12 notes at the end of the Symphony in an exquisite manner.
The Barbirolli recording is available on YouTube.

Other works of VW well worth hearing include the other eight symphonies, especially the 1st or Sea Symphony for chorus and orchestra, the 3rd Pastoral Symphony, Symphonies 5 and 6 from the World War II decade. His ballet Job, the operas Pilgrim’s Progress, the Lark Ascending for violin and orchestra and his arrangements of English hymns and folk songs, etc. All on YouTube.

Stephen King

Stephen King

Maine’s own Stephen King’s latest novel Billy Summers deals with a hit man who only shoots truly bad guys. The story line deals with a two million dollar contract in front of a heavily guarded courthouse and the … but enough said.

President Calvin Coolidge

Calvin Coolidge

YouTube also has several news reels showing former President Calvin Coolidge (1872-1933) at work and on vacation. Because he was very gifted with managing the government with low taxes and a man of few words, he would be worthy of further study by those currently in power.

 

 

 

FINANCIAL FOCUS: Watch out for tax scammers

from Sasha Fitzpatrick

Sadly, identity theft happens throughout the year – but some identity thieves are particularly active during tax-filing season. How can you protect yourself?

One of the most important moves you can make is to be suspicious of requests by people or entities claiming to be from the Internal Revenue Service. You may receive phone calls, texts and emails, but these types of communication are often just “phishing” scams with one goal in mind: to capture your personal information. These phishers can be quite clever, sending emails that appear to contain the IRS logo or making calls that may even seem to be coming from the IRS. Don’t open any links or attachments to the emails and don’t answer the calls – and don’t be alarmed if the caller leaves a vaguely threatening voicemail, either asking for personal information, such as your Social Security number, or informing you of some debts you supposedly owe to the IRS that must be taken care of “immediately.”

In reality, the IRS will not initiate contact with you by phone, email, text message or social media to request personal or financial information, or to inquire about issues pertaining to your tax returns. Instead, the agency will first send you a letter. And if you’re unsure of the legitimacy of such a letter, contact the IRS directly at 800-829-1040.

Of course, not all scam artists are fake IRS representatives – some will pass themselves off as tax preparers. Fortunately, most tax preparers are honest, but it’s not too hard to find the dishonest ones who might ask you to sign a blank return, promise you a big refund before looking at your records or try to charge a fee based on the percentage of your return. Legitimate tax preparers will make no grand promises and will explain their fees upfront. Before hiring someone to do your taxes, find out their qualifications. The IRS provides some valuable tips for choosing a reputable tax preparer, but you can also ask your friends and relatives for referrals.

Another tax scam to watch out for is the fraudulent tax return – that is, someone filing a return in your name. To do so, a scammer would need your name, birthdate and Social Security number. If you’re already providing two of these pieces of information – your name and birthdate on social media, and you also include your birthplace – you could be making it easier for scam artists to somehow get the third. It’s a good idea to check your privacy settings and limit what you’re sharing publicly. You might also want to use a nickname and omit your last name, birthday and birthplace.

Here’s one more defensive measure: File your taxes as soon as you can. Identity thieves often strike early in the tax season, so they can file their bogus returns before their victims.

To learn more about tax scams, visit the IRS website (irs.gov) and search for the “Taxpayer Guide to Identity Theft.” This document describes some signs of identity theft and provides tips for what to do if you are victimized.

It’s unfortunate that identity theft exists, but by taking the proper precautions, you can help insulate yourself from this threat, even when tax season is over.

This article was written by Edward Jones for use by your local Edward Jones Financial Advisor. Edward Jones. Member SIPC.

SCORES & OUTDOORS – Ferrets: Man’s other best friend

Black-footed ferret

Roland D. Halleeby Roland D. Hallee

Don’t ask why or how, but last week, while gathered with friends, I was asked a question about ferrets. Not knowing that much about them, I decided to look into it.

What I discovered about the little furry animals was most interesting.

Although I know a few people who have had ferrets as pets, I didn’t realize they were the third most popular pet, behind only dogs and cats. They are popular, although often controversial. My wife and I had a pet, 10-year-old, Holland lop rabbit. I would have bet, if I were a gambling man, and based on conversations with a multitude of people who care for them, that rabbits were more popular than ferrets.

Ferrets have the size and shape of a zucchini, and are related to European polecats. They are not to be confused with skunks which are sometimes colloquially called polecats, but related more to wolverines, ermines, minks and weasels.

The ancient Greeks probably domesticated ferrets about 2,500 years ago to hunt vermins. The practice spread across Europe, especially with sailors who used ferrets on ships to control rats. Ferrets were introduced to America in the 1700s.

A 1490 painting by Leonardo da Vinci named Lady with an Ermine, actually shows her holding a ferret.

Ferrets are carnivores, meaning they eat only meat. According to the American Ferret Association, domesticated ferrets typically eat factory-made chow. A healthy diet for pet ferrets consist of 36 percent protein, 20 percent fats and is low in carbohydrates. A healthy ferret will sleep up to 18 hours a day.

Male ferrets are known as hobs and females are called jills. In the wild, hobs and jills mate around March and April. Following a gestation period of 35 – 45 days, a jill will give birth to one to six kits. Kits will stay with the mother for about a month and a half, leaving the mother as autumn approaches. They become sexually active at one year old. In captivity ferrets can live up to 12 years, but the actual life expectancy is 7-10 years.

Unlike dogs, ferrets have not yet been rigorously studied when it comes to social cognition. According to Hungarian researchers, their early history in service to man is obscure, but have probably been domesticated for more than 2,000 years through selective breeding. Like dogs, ferrets were originally bred for practical reasons like hunting. However, their role within human society has since shifted, as they are now predominantly pets.

Most ferrets will live happily in social groups. A group of ferrets is commonly referred to as a “business.” They are territorial, like to burrow, and prefer to sleep in an enclosed area.

Ferrets can release their anal gland secretions when startled or scared, but the smell is much less potent than a skunk’s and dissipates rapidly. Most pet ferrets in the U.S. are sold de-scented (anal glands removed).

When excited, ferrets may perform a behavior commonly called the weasel war dance, characterized by a frenzied series of sideways hops, leaps and bumping into nearby objects. Despite its common name, this is not aggressive but is a joyful invitation to play. It is often accompanied by a soft clucking noise, commonly referred to as “dooking.” Conversely, when frightened, ferrets will make a hissing noise; when upset, they will make a soft ‘squeaking’ noise.

Although most domesticated ferrets were introduced by Europeans, there is only one that is native to North America. It is the black-footed ferret, and its existence is in trouble. The U.S. Fish and Wildlife Service is proposing to use unmanned aerial drones to rain peanut-butter laced pellets down on northeast Montana, where the ferrets reside. The pellets contain a vaccine against the plague, which is common in prairie dogs. Prairie dogs consist of 90 percent of the ferret’s diet. As Americans moved west, prairie dog eradication programs and agriculture and development removed much of the ferrets’ prey and habitat, and by 1987 only 18 of the ferrets remained.

The International Union for Conservation of Nature’s (IUCN) Red List of Threatened Species categorizes black-footed ferrets as endangered. There are currently only around 206 mature adults in the wild and their population is decreasing. This is due greatly to the prairie dog population decline since prairie dogs are a major food and shelter source for wild ferrets. They will also eat small mammals such as opossums, rabbits, hedgehogs and rodents, but prairie dogs are the fare of choice.

So, by feeding the prairie dogs with the vaccine they would stay healthy, which in turn would help the black-footed ferrets.

So, domesticated ferrets don’t have it all that bad, like dogs and cats.

Roland’s trivia question of the week:

What is the lowest scoring game in Super Bowl history?

Answer can be found here.

SOLON & BEYOND: Catching up with news from Solon Elementary School

Marilyn Rogers-Bull & Percyby Marilyn Rogers-Bull & Percy
grams29@tds.net
Solon, Maine 04979

Good morning, dear friends. Don’t worry, be happy!

I am so happy to have received the report from the Solon School about all the exciting news about what has been going on there recently.

It starts out like this: Solon Fire Department Presents Fire Safety Programs/; On November 18, two firefighters, Todd and Jenny Rollins, from the Solon Fire Department, visited our school to teach our Pre-5 students about fire safety. This is an annual event every fall to remind students how to keep themselves and their families safe in the event of a fire. The students also learned about all of the safety gear that fire fighters wear and use in fighting fires.

We thank the Solon Fire Department for supporting fire safety programs in our school every day.

The following is from the Principal’s Message: I want to wish all our students and families a Happy New Year. I hope you had a festive holiday season and some special times with family and friends during the Christmas break. The Christmas spirit was alive and well in our community this year!

Many generous individuals and organizations supported our students and families during the Christmas season by donating food baskets, Christmas gifts, winter weather gear, and other items. We thank all of these wonderful people. Solon Congregational Church, New Hope Church and Homeless Shelter , Mrs. Ann Jackson, Mr. Leland McDonough, Mrs. Peggy Luce, Mrs. Terrie Hoops, and the Embden Town Office.

On January 5 our school board will consider extending their mask mandate through March 4 as a way to curb the spread of COVID in our schools and reduce the number of students and staff who have to quarantine. During the month of January we will be administering the NWEA assessment to students in grades K – 5 .

Students took these tests in reading, language use, and math in October and will take them again in May. The winter assessment helps us to check students progress and make adjustments in their instruction if needed.

Holiday Highlights: We enjoyed the Christmas season at Solon Elem­entary School this year. We were still not able to hold events such as a Christmas program or holiday concert due to COVID restrictions, but we did plan some fun activities for our students and staff. We had a Holiday Theme Week with a dress-up theme each day. We did a Secret Santa ornament exchange to make ornaments for others, and those ornaments decorated our Christmas tree. We had a contest to guess how many M&Ms were in a Santa ear jar. And the Solon PTO held a Christmas Shopping Day so students could buy gifts for their family members. The PTO asked each teacher to submit a wish list with items for their classrooms and they shopped for those. M&M contest winners were Xavier Poulin, Kabella Chreitien and Mrs. Rogers.

During the month of November, Solon Elementary School held a Thanksgiving Food Drive to benefit the Solon Food Cupboard. It was very successful, bringing in 581 items. The third grade class collected the most items with 129 with the fifth grade class in second place with 116 items.

I’m going to end this column with words from one of my many little books, this one is called Sunny Thoughts. And it states Words to Keep You Smiling, Shining, and Looking on the Bright Side: Resolve to see the world on the sunny side, and you have almost won the battle of life at the outset. Hope you have a wonderful day!

OPINIONS – A letter to Sen. Susan Collins: Is there a cynical plan to bankrupt USPS?

COMMUNITY COMMENTARY

by Eugene Bryant, of Palermo

This letter was sent to Sen. Susan Collins by Eugene Bryant, of Palermo.

Dear Senator Collins:

First, thanks to you and your staff for your ongoing service in these difficult times. Considering everything else that’s been going on, I’m writing about a somewhat less dramatic issue, the United States Postal Service.

One of the charges I heard leveled against you in the last election was that you had sponsored or supported the bill that mandates the USPS fund, in just a few years, the full retirement and health insurance costs for its employees out for an incredibly long period – is it 70 years? It seems that no other public or private entity has ever been required to do this. This utterly baffled me until I heard the contention that it represents a cynical effort to bankrupt the Postal Service so that private delivery companies such as FedEx and UPS can acquire the most profitable parts of it. If it were not for this unreasonable mandate, the USPS would apparently be showing a decent profit.

People sneer at “snail mail”. But we all take it for granted that the Postal Service will safely and securely carry an original document practically from door to door anywhere in the U.S., usually in three or four days, for little over 50 cents.

I have been the executor for both my mother’s and elder brother’s estates and have depended on first class mail for transferring legal documents and sometimes checks for considerable sums. I never had any problems, until fairly recently.

Since Donald Trump’s appointee took over the Postal Service there has been a noticeable decline in the quality of service. The hours at rural post offices were cut back so that it became more difficult to mail packages or purchase stamps. Then, it was on the news that letter-sorting machines had been arbitrarily removed from many busy regional mail centers, although some were later returned. I understand you helped with that. Thank you.

Last year, I sent a letter to an out-of-state address. Over a month later it came back here as undeliverable – the street number was incorrect. There are fewer than 15 houses on the road to which it was addressed, so I doubt the letter made it as far as the actual postal carrier on the ground. Without exception the men and women I have known who carry the mail the last few miles are dedicated and knowledgeable people who take pride in bringing our letters, periodicals, and packages to their destinations as expeditiously as possible.

Earlier this year I delivered several cases of produce to the Curra family farmstand in Knox – perhaps you know it – it’s just below Knox Four Corners and the (former) Ingraham farm equipment dealership. Peter Curra, who is in his 80s and still works full time on the farm, was out, but later sent me a check for several hundred dollars. He had misplaced my street number and just wrote “Banton Road” on the envelope. There are 20-some homes here on the Banton Road and I’ve been living in this particular one for 45 years. For most of those years, my address was simply RFD #1, Palermo.

About a month later, Pete called me to ask if I’d gotten the check since it hadn’t showed up as cashed on his monthly bank statement. I searched my records and messy desk but couldn’t account for it. Finally, almost two months after it was sent, the letter came back to him as “undeliverable”. Again, I doubt if it made it as far as the Palermo Post Office and our regular mail carrier, Kirby, who is incredibly competent and hard working, and was officially diverted somewhere upstream.

Now I hear that the standard for first class mail delivery is to be slowed by several more days. The lifelines of people who obtain medications and other vital goods and services through the mail will be threatened.

From the earliest days of our nation the postal service was created as one of the essential public functions to help knit together a large and diverse country. Next to Social Security, it remains just about the most popular governmental institution. Please explain, Senator Collins, your past votes on this issue and what you intend to do to ensure the future viability of the United States Postal Service.

(Editor’s note: A reply from Sen. Collins was received and will be printed in next week’s issue.)

Give Us Your Best Shot! for Thursday, January 13, 2022

To submit a photo for this section, please visit our contact page or email us at townline@townline.org!

SNOW SNACK: Jayne Winters, of China, photographed this grey squirrel munching on a nut while peeking out of a snow bank.

REGULARS: Regular visitors to the home of Gary Kennedy, and his wife Julie, in Chelsea is this female red fox and her kits.

Give Us Your Best Shot! for Thursday, January 6, 2022

To submit a photo for this section, please visit our contact page or email us at townline@townline.org!

GUARDING THE CACHE: Joan Chaffee, of Clinton, snapped this mourning dove guarding the bird feeder.

TALL ONE: Pat Clark, of Palermo, photographed this tall common mullein growing in her backyard.

FALL REFLECTION: Merilee Kelly, of Palermo, captured this reflective fall scene on Branch Pond.

FOR YOUR HEALTH: Ring In The New Year With An ‘Anti’ Resolution List

The JRNY digital fitness platform features hundreds of workouts including strength, cardio, HIIT, yoga, stretching and Pilates. JRNY is integrated with Bowflex cardio equipment such as the Max Total 16 and features workouts perfect for use with the Bowflex SelectTech 552 and 1090 dumbbells.

(NAPSI)—As the world celebrates the new year, many will make an annual list of resolutions and goals, which often include improving overall health and fitness.

As we continue to weather the COVID-19 pandemic, improving overall health is front and center, more so than usual. However, according to the U.S. New Year’s Resolutions 2020 study conducted by YouGov, over half of those who set New Year’s resolutions can’t follow through.
Luckily, exercise physiologist and Bowflex fitness advisor Tom Holland has a new approach to setting and reaching your health and fitness goals this year.
Focus on Anti-Resolutions
Holland recommends turning the typical New Year’s resolutions list on its head by creating “anti-resolutions” to focus on what you’re not going to do. For example, instead of saying “I’m going to work out every day” or “eat only healthy foods,” resolve to not make excuses. This can take the focus off the broader goal and onto in-the-moment actions. The next time you plan to go the gym or cook a healthy meal, and you start to come up with reasons today’s not the day, you can remember your resolution to not make excuses. If you set unrealistic resolutions to transform your entire lifestyle all at once, it’s more difficult to take the necessary steps to get there.
Most people have made excuses for not making a workout or sticking to a routine. This anti-resolution approach changes the focus from overly ambitious goals to a more subtle mindset shift.
To help you continue or take those first steps on your fitness journey, Holland also recommends connected fitness services and apps, such as the JRNY digital fitness platform (https://www.bowflex.com/jrny.html). With the JRNY app, you can easily fit exercise into your schedule with a wide range of personalized, trainer-led workouts. JRNY is integrated with Bowflex cardio equipment, including stationary bikes and treadmills, and features off-product workouts such as HIIT, strength, yoga, stretch and Pilates, which can be accessed from a mobile device or tablet via the JRNY app. So many options means no more excuses. No matter your fitness level, goals or lifestyle, JRNY has exercise programs to help you stay motivated and active so you can make exercise a habit in your life.

Determine What Works Best for You

Often people struggle to get started working out because they think they need to go to the gym all the time or sacrifice privacy, comfort and entertainment to see results. Holland notes that it’s important to not let trends, other people’s opinions or even your own preconceived notions get in the way.
It’s easier than ever before to find a workout routine that aligns with your lifestyle. If going to the gym isn’t your speed, you could pick up a versatile fitness product such as a set of Bowflex SelectTech 552 dumbbells (https://www.bowflex.com/selecttech/552/100131.html) or download the JRNY mobile app (https://www.bowflex.com/jrny/subscribe/checkout) for access to hundreds of video workouts that can be done from the comfort of your own home—no expensive gym membership or commute required.
If you find your motivation is dwindling, the Bowflex Max Total 16 (https://www.bowflex.com/max-trainer/mt16/100915.html) is a great option that lets you do high-intensity, interval workouts at home while streaming your entertainment subscriptions including Netflix, Hulu, Amazon Prime Video, HBO Max, and Disney+.
This new year, try a different approach to health and fitness resolutions by kicking the overly ambitious goals of the past to the side in favor of setting anti-resolutions instead. At the same time, take advantage of what today’s fitness technology has to offer to improve your odds of success and make this your year.

MAINE MEMORIES: Cock-a-Doodle-Do!

Bantam chicken (left), Bantam Rooster (right).

by Evangeline T.

Hello and welcome to Maine Memories, little snippets of life from our home state.

For this installment, I’m remembering when I raised chickens.

At about age 12, each girl in a club I belonged to had to do a summer project.

Being raised on a farm, I opted to raise bantam chickens. Bantams aren’t as big as regular chickens and are sometimes referred to as miniatures. I had two females and one rooster.

Now Bantams, at least mine, could fly, not too far, 200 feet or so and not high up in the air, maybe 20 feet. My point is, a fenced in yard wasn’t much help, as each day they flew over the fence and out.

Dad fixed that problem. He trimmed some feathers on one wing of each bird. Trimming didn’t hurt them in any way, but they’d become off-balanced when flying. It worked on the females, but let me tell you, that frisky little rooster continued with his messy daily flights, off balance or not!

Our driveway was a circle, which had a section of lawn and a pine tree in it. That rooster loved to fly and perch himself in the pine tree every morning. If you have ever visited or lived on a farm that had a rooster, you’ve probably heard an early morning sunrise “cock-a-doodle do”! My bantam rooster had a problem; his voice wouldn’t produce a nice morning “cock a doodle do”. It came out sounding more like rough-a-rough, ending sharply. Each morning at sun rise, he’d sit in that pine and try again and again, but the sound was always the same.

You have to give him credit, though. He never gave up, and his rough-a-rough lives on in my memory.

There’s a lesson here we can all take to heart: keep on trying. You just might get it right! Cock-a-doodle-do!